Was this machine working with LR and IE previously? If so, what has changed?
Have you disabled Data Execution Prevention (DEP)?
To disable DEP from command prompt, run this:
bcdedit.exe /set nx AlwaysOff
Do you have User Account Control (UAC) disabled also?
To disable UAC from command prompt (NOTE: this will require a reboot), run this:
REG ADD HKLM\Software\Microsoft\Windows\CurrentVersion\Policies\System /v EnableLUA /t REG_DWORD /d 0x0 /f
